hMENA isoforms regulate cancer intrinsic type I IFN signaling and extrinsic mechanisms of resistance to immune checkpoint blockade in NSCLC.
Paola TronoAnnalisa TocciBelinda PalermoAnna Di CarloLorenzo D'AmbrosioDaniel D'AndreaFrancesca Di ModugnoFrancesca De NicolaFrauke GoemanGiacomo CorleoneSarah H WarrenFrancesca PaoliniMariangela PanettaIsabella SperdutiSilvia BaldariPaolo ViscaSilvia CarpanoFederico CappuzzoVincenzo RussoClaudio TripodoPaolo ZucaliVanesa GregorcFederica MarchesiPaola NisticoPublished in: Journal for immunotherapy of cancer (2023)
in modulating cancer cell intrinsic type I IFN signaling and extrinsic mechanisms that promote protumoral macrophages and favor EMT. These data highlight the role of actin cytoskeleton disturbance in activating immune suppressive pathways that may be involved in resistance to ICB in NSCLC.