Association of TP53 and CDKN2A Mutation Profile with Tumor Mutation Burden in Head and Neck Cancer.
Alexander Y DenekaYasmine BacaIlya G SerebriiskiiEmmanuelle NicolasMitchell I ParkerTheodore T NguyenJoanne XiuWolfgang Michael KornMichael J DemeureTrisha Michel Wise-DraperAmmar SukariBarbara BurtnessErica A GolemisPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
These data emphasize the role of tumor subsite in evaluation of mutational profiles in HNSCC, and link defects in TP53 and CDKN2A to elevated TMB levels in some tumor subgroups.