Hypothalamic NR3C1 DNA methylation in rats exposed to prenatal stress.

Kuyaş Hekimler ÖztürkGülin Özdamar ÜnalDuygu Kumbul DoğuçVehbi Atahan ToğayPınar Aslan KoşarMekin Sezik

Published in: Molecular biology reports (2022)

Our results confirm the relationship between PS and epigenetic changes of HPA axis-related genes and show that NR3C1 gene methylation status in pups is sensitive to PS during pregnancy. Environmental maternal stress may have transgenerational effects that are potentially associated with adverse outcomes in the pups.

Keyphrases

dna methylation
genome wide
gene expression
copy number
pregnant women
stress induced
birth weight
human health
heat stress
gestational age