Aqueous mediated iodine catalyzed C-N coupling followed by C-C coupling towards 5 H -pyrazino[2,3- b ]indoles.

Our study describes a new development featuring iodine-catalyzed two consecutive oxidative cross-coupling reactions involving C α (sp 3 )-H of benzyl amines followed by intramolecular cyclization in water under air. Here, C-N coupling followed by C-C coupling occurs in a green environment to provide a variety of 5 H -pyrazino[2,3- b ]indoles within a short time period.