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The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis.

Joanna N SkhinasThomas R Cox
Published in: Cell adhesion & migration (2017)
The extracellular matrix (ECM) is a master regulator of cellular phenotype and behaviour. It plays a crucial role in both normal tissue homeostasis and complex diseases such as cancer. The interplay between the intrinsic factors of cancer cells themselves, including their genotype and signalling networks; and the extrinsic factors of the tumour stroma, such as the ECM and ECM remodelling; together determine the fate and behaviour of cancer cells. As a consequence, tumour progression, metastatic spread and response to therapy are ultimately controlled by ECM-driven fine-tuning of intracellular kinase signalling. The ability to target and uncouple this interaction presents an emerging and promising potential in the treatment of cancer.
Keyphrases
  • extracellular matrix
  • papillary thyroid
  • squamous cell
  • squamous cell carcinoma
  • tyrosine kinase
  • childhood cancer
  • stem cells
  • mesenchymal stem cells
  • protein kinase
  • young adults
  • climate change