TGF-β2 silencing to target biliary-derived liver diseases.
Anne DropmannSteven DooleyBedair DewidarSeddik HammadTatjana DediuliaJulia WerleVanessa HartwigShahrouz GhafooryStefan WoelflHanna KorhonenMichel JanicotKatja WosikowskiTimo ItzelAndreas TeufelVictor F ZevallosAna StojanovicAdelheid CerwenkaStefanie NittkaAlbrecht PiiperTimo GaiserNaiara BerazaMalgorzata MilkiewiczPiotr MilkiewiczJohn G BrainDavid E J JonesThomas S WeissUlrich M ZangerMatthias EbertNadja M Meindl-BeinkerPublished in: Gut (2020)
Taken together, our data suggest a new mechanistic explanation for amelioration of fibrogenesis by TGF-β2 silencing and provide a direct rationale for TGF-β2-directed drug development.