Transcriptome-Based Prognostic and Predictive Biomarker Analysis of ENACT: A Randomized Controlled Trial of Enzalutamide in Men Undergoing Active Surveillance.

Ashley Evan RossKenneth K IwataDina ElsoudaJohn C HairstonDavid RussellElai DavicioniJames A ProudfootNeal D ShoreEdward M Schaeffer

Published in: JCO precision oncology (2024)

This analysis suggests that the Decipher genomic classifier may be prognostic for disease progression in AS patients with low- to intermediate-risk prostate cancer. Higher Decipher and AR-A scores, as well as PAM50 luminal subtypes, may also serve as biomarkers for treatment response.

Keyphrases

prostate cancer
radical prostatectomy
gene expression
rna seq
copy number
dna methylation