Changes of the serum properties and its effect on the endothelial cells restoration in patients with chronic venous disease treated with sulodexide.
Adam ZielińskiKatarzyna Jasińska-SumińskaAndrzej BręborowiczKatarzyna KowalskaMaciej ZabelTeresa WysockaRaouf A KhalilJoseph D RaffettoTomasz UrbanekPublished in: Journal of vascular surgery. Venous and lymphatic disorders (2024)
The study documented the significant proinflammatory human vascular endothelial cell activation when exposed to the serum collected from the varicose veins as compared with the serum from the systemic circulation in patients with chronic venous disease (CVD). The inflammatory marker expression, endothelial dysfunction, and endothelial cell senescence transformation can be successfully controlled and downregulated by patients' exposure to the glycosaminoglycan (sulodexide) treatment. Further studies are needed to confirm if glycosaminoglycan application can prevent further CVD clinical progression due to potential CVD-related pathological processes' modulation and their downregulation.
Keyphrases
- endothelial cells
- high glucose
- newly diagnosed
- end stage renal disease
- vascular endothelial growth factor
- ejection fraction
- chronic kidney disease
- poor prognosis
- cell proliferation
- prognostic factors
- oxidative stress
- risk assessment
- combination therapy
- pulmonary embolism
- binding protein
- long non coding rna
- drug induced
- human health