Potential benefit of treatment with MEK inhibitors and chemotherapy in BRAF-mutated KRAS wild-type pancreatic ductal adenocarcinoma patients: a case report.
Bach ArdalanJose Ignacio AzquetaJonathan EnglandTiffany Alyssa EatzPublished in: Cold Spring Harbor molecular case studies (2021)
This is the first case report of a 60-yr-old female who underwent therapy for metastatic pancreatic cancer with fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX). Upon the progression of her disease, she was switched to gemcitabine and nab-paclitaxel. Per genomic sequencing, her tumor was found to be a KRAS wild-type and BRAF V600E mutation, which then warranted treatment with the MEK1 and MEK2 inhibitor, cobimetinib. The patient has achieved a complete response (CR) to a combination of gemcitabine, nab-paclitaxel, and cobimetinib. It has been 16 mo since the start of the treatment, and the patient continues to demonstrate a complete durable response both serologically and radiologically.
Keyphrases
- wild type
- case report
- locally advanced
- small cell lung cancer
- squamous cell carcinoma
- radiation therapy
- gene expression
- pi k akt
- risk assessment
- newly diagnosed
- combination therapy
- single cell
- chronic kidney disease
- advanced non small cell lung cancer
- copy number
- patient reported outcomes
- cell proliferation
- replacement therapy
- peritoneal dialysis