Login / Signup

Incidental FOXL2 mutated adult granulosa cell tumour of the ovary with thecoma-like foci.

Anne Kristin FischerBirgid Schömig-MarkiefkaCarina HeydtDominik RatiuPeter MallmannJörn MeinelReinhard BüttnerDietmar SchmidtAlexander Quaas
Published in: Virchows Archiv : an international journal of pathology (2022)
We report on the incidental finding of a FOXL2 mutated adult granulosa cell tumour of the ovary with thecoma-like foci, a rare entity recently described by Jennifer N. Stall and Robert H. Young in a series of sixteen cases in 2019, displaying features differing from conventional adult granulosa cell tumour. Our aim is to specify the morphologic and molecular particularities of this presumably underrecognized finding, with a short presentation of the typical clinical context. Awareness of this rare and challenging neoplasm with indeterminate clinical course is crucial in routine diagnostics.
Keyphrases
  • single cell
  • cell therapy
  • polycystic ovary syndrome
  • stem cells
  • type diabetes
  • metabolic syndrome
  • bone marrow
  • clinical practice
  • insulin resistance
  • childhood cancer
  • skeletal muscle
  • ultrasound guided