Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics.

Martin Kuric Susanne Beck Doris Schneider Wyonna Darleen Rindt Marietheres Evers Jutta Meißner-Weigl Sabine Zeck Melanie Krug Marietta Herrmann Tanja Nicole Hartmann Ellen Leich Maximilian Rudert Denitsa Docheva Anja Seckinger Dirk Hose Franziska Jundt Regina Ebert

Published in: Cancer research communications (2024)

Novel methods describe in vitro dissemination of myeloma cells as detachment of daughter cells after cell division. Myeloma adhesion genes were identified that counteract in vitro detachment with potential clinical relevance.

Keyphrases

induced apoptosis
cell cycle arrest
multiple myeloma
endoplasmic reticulum stress
cell death
gene expression
stem cells
genome wide
risk assessment
mesenchymal stem cells
transcription factor
cystic fibrosis
protein kinase
human health