Effect of ageing on antiretroviral drug pharmacokinetics using clinical data combined with modelling and simulation.

Felix Stader Perrine CourletHannah KinvigManuel BattegayLaurent A DecosterdMelissa A PennyMarco SiccardiCatia Marzolini

Published in: British journal of clinical pharmacology (2020)

Dose adjustment for antiretrovirals based on the age of male and female PLWH is a priori not necessary in the absence of severe comorbidities considering the large safety margin of the current first-line HIV treatments.

Keyphrases

hiv infected
hiv positive
human immunodeficiency virus
antiretroviral therapy
hiv aids
men who have sex with men
hiv infected patients
hiv testing
hepatitis c virus
south africa
electronic health record
drug induced
early onset
big data
emergency department
virtual reality
machine learning