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Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology.

Keming LinBaijin XiaXuemei WangXin HeMo ZhouYingtong LinYidan QiaoRong LiQier ChenYuzhuang LiJinzhu FengTao ChenCancan ChenXinyu LiHui ZhangLijuan LuBingfeng LiuXu Zhang
Published in: Journal of translational medicine (2024)
In summary, the results of this study suggest that the CAR-T cells derived from high specificity and high affinity Nbs, targeting FGFR4, exhibited significantly enhanced anti-tumor efficacy in vitro and in vivo. This is an exploration of FGFR4 in the field of Nb-derived CAR-T cell therapy for HCC, holding promise for enhancing safety and effectiveness in the clinical treatment of HCC in the future.
Keyphrases
  • cancer therapy
  • systematic review
  • current status
  • big data
  • drug delivery
  • machine learning
  • artificial intelligence