Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B.

Valentina SvicherRomina SalpiniLorenzo PiermatteoLuca CariotiArianna BattistiLuna ColagrossiRossana ScutariMatteo SurdoValeria CacciafestaAndrea NuccitelliNavjyot HansiFrancesca Ceccherini SilbersteinCarlo Federico PernoUpkar S GillPatrick T F Kennedy

Published in: Gut (2020)

HBV DNA integration occurs across all HBeAg-negative patients with CHB, including those with a limited HBV reservoir; localising in genes involved in carcinogenesis and altering the hepatocyte transcriptome.

Keyphrases

hepatitis b virus
liver failure
circulating tumor
cell free
single molecule
gene expression
nucleic acid
dna methylation
water quality