Histogram Analysis of Perfusion Parameters from Dynamic Contrast-Enhanced MR Imaging with Tumor Characteristics and Therapeutic Response in Locally Advanced Rectal Cancer.
Dong Myung YeoSoon Nam OhMoon Hyung ChoiSung Hak LeeMyung Ah LeeSeung Eun JungPublished in: BioMed research international (2018)
These preliminary results suggest that a larger proportion of higher AUC skewness was present in LN metastasis group and a higher vp histogram value was present in rectal cancer with PNI. In addition, Ktrans and kep histogram parameters showed difference according to the KRAS mutation, demonstrating the utility of the histogram of perfusion parameters derived from DCE-MRI as potential imaging biomarkers of tumor characteristics and genetic features.
Keyphrases
- contrast enhanced
- rectal cancer
- locally advanced
- diffusion weighted
- magnetic resonance imaging
- diffusion weighted imaging
- magnetic resonance
- computed tomography
- neoadjuvant chemotherapy
- phase ii study
- squamous cell carcinoma
- high resolution
- radiation therapy
- genome wide
- gene expression
- human health
- photodynamic therapy
- risk assessment
- study protocol