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Genotype and phenotype distribution of 435 patients with Charcot-Marie-Tooth disease from central south China.

Yongzhi XieZhiqiang LinLei LiuXiaobo LiShunxiang HuangHuadong ZhaoBinghao WangSen ZengWanqian CaoLu LiXiying ZhuSiwei HuangHonglan YangMengli WangZhengmao HuJun-Ling WangJi-Feng GuoLu ShenJiang HongStephan ZuchnerBeisha TangRuxu Zhang
Published in: European journal of neurology (2021)
Our results provided a unique genotypic and phenotypic landscape of patients with CMT and related disorders from central south China, including a relatively high proportion of CMT2 and lower occurrence of PMP22 duplication. The broad phenotype spectra in certain genes have advanced our understanding of CMT.
Keyphrases
  • risk assessment
  • genome wide
  • single cell
  • density functional theory
  • dna methylation
  • molecular dynamics
  • genome wide analysis