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Polypharmacy during pregnancy and associated risk factors: a retrospective analysis of 577 medication exposures among 1.5 million pregnancies in the UK, 2000-2019.

Anuradhaa SubramanianAmaya Azcoaga-LorenzoAstha AnandKatherine PhillipsSiang Ing LeeNeil CockburnAdeniyi Francis FagbamigbeChristine Damase-MichelChristopher YauColin McCowanDermot O'ReillyGillian SantorelliHolly F HopeJonathan Ian KennedyKathryn Mary AbelKelly-Ann EastwoodLouise LocockMairead BlackMaria A LoaneNgawai MossRachel PlachcinskiShakila ThangaratinamSinead BrophyUtkarsh AgrawalZoe VowlesPeter BrocklehurstHelen DolkCatherine Nelson-PiercyKrishnarajah Nirantharakumarnull null
Published in: BMC medicine (2023)
The prevalence of polypharmacy during pregnancy has increased over the past two decades and is particularly high in younger and older women; women with high BMI, smokers and ex-smokers; and women with multimorbidity, higher gravidity and higher levels of deprivation. Well-conducted pharmaco-epidemiological research is needed to understand the effects of multiple medication use on the developing foetus.
Keyphrases
  • smoking cessation
  • adverse drug
  • body mass index
  • risk factors
  • healthcare
  • air pollution
  • preterm birth
  • pregnant women
  • drug induced