Epitope specificity determines cross-protection of a SIT-induced IgG4 antibody.
E GadermaierLouisa Katherine JamesM H ShamjiK BlattK FaulandP ZieglmayerT GarmatiukM Focke-TejklM VillalbaR BeavilWalter KellerP ValentS R DurhamH J GouldS FlickerR ValentaPublished in: Allergy (2015)
Our results demonstrate that a small number of amino acid differences among cross-reactive allergens can reduce the affinity of binding by a SIT-induced IgG and thus limit cross-protection.