Acute simvastatin treatment restores cerebral functional capillary density and attenuates angiotensin II-induced microcirculatory changes in a model of primary hypertension.

Felipe FreitasVanessa EstatoPatricia ReisHugo C Castro-Faria-NetoVinícius CarvalhoRafael TorresMarcos A LessaEduardo Tibiriçá

Published in: Microcirculation (New York, N.Y. : 1994) (2018)

The antihypertensive effect of SIM is associated with an improvement in cerebral microvascular perfusion and capillary density that may help to prevent hypertension-induced cerebrovascular damage independent of cholesterol-lowering.

Keyphrases

angiotensin ii
blood pressure
high glucose
drug induced
diabetic rats
subarachnoid hemorrhage
oxidative stress
vascular smooth muscle cells
hypertensive patients
magnetic resonance imaging
endothelial cells
magnetic resonance
cerebral ischemia
brain injury