Clinicogenomic predictors of outcomes in patients with hepatocellular carcinoma treated with immunotherapy.

Darren CowzerJoanne F ChouHenry S WalchFergus KeaneDanny KhalilJinru ShiaRichard K G DoHooman YarmohammadiJoseph P ErinjeriImane El DikaAmin YaqubieHassan AzhariMaya GambarinCarla HajjChristopher CraneAlice C WeiWilliam JarnaginDavid B SolitMichael F BergerEileen M O'ReillyNikolaus SchultzWalid K ChatilaMarinela CapanuGhassan K Abou-AlfaJames J Harding

Published in: The oncologist (2024)

Clinicopathologic factors were the major determinates of outcomes for patients with advanced HCC treated with ICI. Molecular profiling did not aid in stratification of ICI outcomes. Future studies should explore alternative biomarkers such as the level of immune activation or the pretreatment composition of the immune tumor microenvironment.

Keyphrases

type diabetes
metabolic syndrome
adipose tissue
single molecule
weight loss
case control