Absence of B Cells in Brainstem and White Matter Lesions Associates With Less Severe Disease and Absence of Oligoclonal Bands in MS.
Nina L FransenBrigit A de JongKatharina HeßTanja KuhlmannMaria C J VincentenJörg HamannInge HuitingaJoost J F M SmoldersPublished in: Neurology(R) neuroimmunology & neuroinflammation (2021)
The absence of B cells is associated with a favorable clinical and pathological profile. This finding may reflect extremes of a continuum of genetic or environmental constitution, but also a regression of WM humoral immunopathology in the natural course of advanced MS.