Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma.

Yasmine HachemiSimon PerrinMaria EthelAnais JulienJulia VetteseBlandine GeislerChristian GöritzCéline Colnot

Published in: bioRxiv : the preprint server for biology (2024)

Hachemi et al. report the immune cell atlas of bone repair revealing macrophages as pro-fibrotic regulators and a therapeutic target for musculoskeletal regeneration. Genetic depletion or pharmacological inhibition of macrophages improves bone healing in musculoskeletal trauma.

Keyphrases

bone mineral density
soft tissue
bone loss
stem cells
bone regeneration
single cell
genome wide
trauma patients
systemic sclerosis
body composition
pain management
dna methylation
copy number
chronic pain