An apoptosis inhibitor suppresses microglial and astrocytic activation after cardiac ischemia/reperfusion injury.

Suchan LiaoYing LuoTitikorn ChunchaiKodchanan SinghanatBusarin ArunsakJuthipong BenjanuwattraNattayaporn ApaijaiNipon ChattipakornSiripron C Chattipakorn

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2022)

Z-VAD exerts neuroprotective effects against cardiac I/R injury not only targeting apoptosis but also microglial and astrocyte activation.

Keyphrases

oxidative stress
ischemia reperfusion injury
endoplasmic reticulum stress
cell cycle arrest
inflammatory response
left ventricular
lipopolysaccharide induced
cell death
lps induced
neuropathic pain
signaling pathway
cancer therapy
heart failure
spinal cord injury
spinal cord
drug delivery
cell proliferation