Guillain-Barré syndrome related to Zika virus infection: A systematic review and meta-analysis of the clinical and electrophysiological phenotype.
Sonja E LeonhardCristiane C Bresani-SalviJoanna D Lyra BatistaSergio CunhaBart C JacobsMaria Lucia Brito FerreiraMaria de Fatima P Militão de AlbuquerquePublished in: PLoS neglected tropical diseases (2020)
The clinical phenotype of GBS associated with ZIKV infection reported in literature is generally a sensorimotor demyelinating GBS with frequent facial palsy and a severe disease course often necessitating ICU admittance. Time between infectious and neurological symptoms and negative PCR in most cases suggests a post-infectious disease mechanism. Heterogeneity between studies was considerable and results may be subject to reporting bias. This study was registered on the international Prospective Register of Systematic Reviews (CRD42018081959).