Mesenchymal stem cells ameliorate renal fibrosis by galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat.

Huajun TangPeiyue ZhangLianlin ZengYu ZhaoLibo XieBo Chen

Published in: Stem cell research & therapy (2021)

The mechanism of MSCs anti-renal fibrosis was probably mediated by galectin-3/Akt/GSK3β/Snail signaling pathway. Galectin-3 may be a valuable target for treating renal fibrosis.

Keyphrases

signaling pathway
epithelial mesenchymal transition
pi k akt
mesenchymal stem cells
induced apoptosis
umbilical cord
cell proliferation
oxidative stress
liver fibrosis
drug induced