Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas.

Justyna M PrzystalChiara Cianciolo CosentinoSridevi YadavilliJie ZhangSandra LaternserErin R BonnerRachna PrasadAdam A DawoodNina LobetoWai Chin ChongMatt C BieryCarrie MyersJames M OlsonEshini PanditharatnaBettina KritzerSulayman MourabitNicholas A VitanzaMariella G FilbinGeoffry N de IuliisMatthew D DunCarl KoschmannJason E CainMichael A GrotzerSebastian M WaszakSabine MuellerJavad Nazarian

Published in: Neuro-oncology (2022)

Targeting mitochondrial metabolism and ISR activation effectively impairs DMG tumorigenicity. These results supported the initiation of two pediatric clinical trials (NCT05009992, NCT04732065).

Keyphrases

clinical trial
single cell
high grade
oxidative stress
low grade
cell therapy
cancer therapy
stem cells
phase ii
open label
drug delivery
cell fate