Nogo-A reduces ceramide de novo biosynthesis to protect from heart failure.
Linda SassetOnorina Laura ManzoYi ZhangAlice MarinoLuisa RubinelliMaria Antonietta RiemmaMadhavi Latha S ChalasaniDragos C DasoveanuFiorentina RoviezzoStanislovas S JankauskasJoseph H TaubeMaria Rosaria BucciTheresa T LuAnnarita Di LorenzoPublished in: Cardiovascular research (2022)
Mechanistically, Nogo-A refrains ceramides from accrual, therefore preserves the "beneficial" autophagy, mitochondrial function, and metabolic gene expression, limiting the progression to HF under sustained stress.