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Evaluation of the incremental prognostic value of the combination of CYP2C19 poor metabolizer status and ABCB1 3435 TT polymorphism over conventional risk factors for cardiovascular events after drug-eluting stent implantation in East Asians.

Mahn-Won ParkSung Ho HerChan Joon KimJung SunChoGyung-Min ParkTae-Seok KimYun-Seok ChoiChul-Soo ParkYoon-Seok KohHun-Jun ParkPum-Joon KimWook-Sung ChungKi-Bae SeungHo-Sook KimJae-Gook ShinKiyuk Chang
Published in: Genetics in medicine : official journal of the American College of Medical Genetics (2015)
In a real-world East Asian PCI population taking clopidogrel, although the concurrent presence of CYP2C19 PM and ABCB1 TT is a strong independent predictor of adverse outcomes, the combined status of two at-risk variants does not have an incremental prognostic value beyond that of the conventional clinical risk factors.Genet Med 18 8, 833-841.
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