Evaluation of the incremental prognostic value of the combination of CYP2C19 poor metabolizer status and ABCB1 3435 TT polymorphism over conventional risk factors for cardiovascular events after drug-eluting stent implantation in East Asians.
Mahn-Won ParkSung Ho HerChan Joon KimJung SunChoGyung-Min ParkTae-Seok KimYun-Seok ChoiChul-Soo ParkYoon-Seok KohHun-Jun ParkPum-Joon KimWook-Sung ChungKi-Bae SeungHo-Sook KimJae-Gook ShinKiyuk ChangPublished in: Genetics in medicine : official journal of the American College of Medical Genetics (2015)
In a real-world East Asian PCI population taking clopidogrel, although the concurrent presence of CYP2C19 PM and ABCB1 TT is a strong independent predictor of adverse outcomes, the combined status of two at-risk variants does not have an incremental prognostic value beyond that of the conventional clinical risk factors.Genet Med 18 8, 833-841.
Keyphrases
- cardiovascular events
- coronary artery disease
- risk factors
- percutaneous coronary intervention
- acute coronary syndrome
- antiplatelet therapy
- cardiovascular disease
- acute myocardial infarction
- air pollution
- copy number
- st elevation myocardial infarction
- locally advanced
- heavy metals
- type diabetes
- atrial fibrillation
- radiation therapy
- risk assessment
- genome wide