Hepatitis B virus P protein initiates glycolytic bypass in HBV-related hepatocellular carcinoma via a FOXO3/miRNA-30b-5p/MINPP1 axis.

Wenbiao ChenJingjing JiangLan GongZheyue ShuDairong XiangXujun ZhangKefan BiHongyan Diao

Published in: Journal of experimental & clinical cancer research : CR (2021)

Our study found that the HBp/FOXO3/miRNA-30b-5p/MINPP1 axis contributes to the development of HBV-positive HCC cells through the glycolytic bypass. We also presented miRNA-30b-5p/MINPP1 as a novel biomarker for HBV-positive HCC early diagnosis and a potential pharmaceutical target for antitumor therapy.

Keyphrases

hepatitis b virus
liver failure
induced apoptosis
transcription factor
pi k akt
signaling pathway
cell cycle arrest
protein protein
endoplasmic reticulum stress
binding protein
small molecule
stem cells
oxidative stress
bone marrow
cell proliferation
amino acid
smoking cessation