Effect of obstructive sleep apnea on glucose metabolism.
Han-Chow E KohStephan van VlietChao CaoBruce W PattersonDominic N ReedsRichard LaforestRobert J GroplerYo-El S JuBettina MittendorferPublished in: European journal of endocrinology (2022)
These data demonstrate that OSA is a key determinant of insulin sensitivity in people with obesity and underscore the importance of taking OSA status into account when evaluating metabolic function in people with obesity. These findings may also have important clinical implications because disease progression and the risk of diabetes-related complications vary by T2D subtype (i.e. severe insulin resistance vs insulin deficiency). People with OSA may benefit most from the targeted treatment of peripheral insulin resistance and early screening for complications associated with peripheral insulin resistance.
Keyphrases
- insulin resistance
- obstructive sleep apnea
- type diabetes
- positive airway pressure
- glycemic control
- high fat diet induced
- metabolic syndrome
- adipose tissue
- high fat diet
- skeletal muscle
- polycystic ovary syndrome
- risk factors
- sleep apnea
- electronic health record
- chemotherapy induced
- early onset
- replacement therapy
- big data
- weight loss
- combination therapy
- data analysis