Multifunctional Glyco-Nanosheets to Eradicate Drug-Resistant Bacteria on Wounds.
Zhong GuoJing-Xi HeSurendra H MahadevegowdaShu Hui KhoMary B Chan-ParkXue-Wei LiuPublished in: Advanced healthcare materials (2020)
Bacterial infection is becoming increasingly lethal with the emergence of antimicrobial resistance, and wounds plagued by such infection are notoriously difficult to heal. Here, the first use of galactose-black phosphorus nanosheets, (Gal-BP NSs) as a delivery platform for synergistic antibiotic (kanamycin, Kana) and photothermal treatments against the Gram-negative microbial strain, Pseudomonas aeruginosa PAO1 (PAO1) is reported. Gal-BP NSs@Kana can actively target PAO1 and release kanamycin into the bacterial cytoplasm upon near-infrared laser irradiation. This strategy kills most of the PAO1 through a simultaneous burst of intracellular kanamycin release and photothermal treatment. Comparable antibacterial activities of Gal-BP NSs@Kana are observed within in vivo mouse models at their wound sites. In addition, this platform accelerates wound healing from PAO1 infection via promotion of neoangiogenesis and collagen production at the wound sites. This work demonstrates the material properties of Gal-BP NS in fighting bacterial infections and in the treatment of wound healing.
Keyphrases
- wound healing
- drug resistant
- multidrug resistant
- gram negative
- antimicrobial resistance
- pseudomonas aeruginosa
- cancer therapy
- acinetobacter baumannii
- drug delivery
- photodynamic therapy
- high throughput
- mouse model
- metal organic framework
- staphylococcus aureus
- combination therapy
- highly efficient
- escherichia coli
- reactive oxygen species
- high frequency
- high speed
- candida albicans
- single cell
- high resolution