Effects of conditioned pain modulation on Capsaicin-induced spreading muscle hyperalgesia in humans.
Jürg SchliessbachAndreas SiegenthalerThomas Graven-NielsenLars Arendt-NielsenMichele CuratoloPublished in: Scandinavian journal of pain (2023)
The results suggest that facilitating CPM is associated with more spreading hyperalgesia than inhibitory CPM. This implies that poor endogenous pain modulation may predispose to muscle pain and spreading hyperalgesia after injury, and suggest that strategies to enhance endogenous pain modulation may provide clinical benefits.