Coupling sparse Cox models with clustering of longitudinal transcriptomics data for trauma prognosis.

The proposed framework was able to tackle the joint analysis of time-to-event information with longitudinal multivariate high-dimensional data. The application to length of stay and transcriptomics data revealed a strong relationship between gene expression trajectory and patients' recovery, which may improve trauma patient's management by healthcare systems. The proposed methodology can be easily adapted to other medical data, towards more effective clinical decision support systems for health applications.