Mitochondrial control of proteasomal Psmb5 drives the differentiation of tissue-resident memory T cells in patients with rheumatoid arthritis.

Tong WuDanhua SuLei ZhangTing LiuQianliang WangChenchu YanMengdi LiuHuiyan JiJiaxin LeiMing ZhengZhenke Wen

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

Mitochondrial succinyl-CoA fosters the succinylation of BRD2, resulting in compromised transcription of proteasomal Psmb5 and the differentiation of Trm cells in RA.

Keyphrases

oxidative stress
induced apoptosis
cell cycle arrest
rheumatoid arthritis
patient safety
working memory
transcription factor
quality improvement
endoplasmic reticulum stress
signaling pathway
ankylosing spondylitis