The Role of the Interleukin-1 Family in Complications of Prematurity.
Elys A GreenSteven P GarrickBriana PetersonPhilip J BergerRobert GalinskyRodney W HuntSteven X ChoJane E BourkeMarcel F NoldClaudia A Nold-PetryPublished in: International journal of molecular sciences (2023)
Preterm birth is a major contributor to neonatal morbidity and mortality. Complications of prematurity such as bronchopulmonary dysplasia (BPD, affecting the lung), pulmonary hypertension associated with BPD (BPD-PH, heart), white matter injury (WMI, brain), retinopathy of prematurity (ROP, eyes), necrotizing enterocolitis (NEC, gut) and sepsis are among the major causes of long-term morbidity in infants born prematurely. Though the origins are multifactorial, inflammation and in particular the imbalance of pro- and anti-inflammatory mediators is now recognized as a key driver of the pathophysiology underlying these illnesses. Here, we review the involvement of the interleukin (IL)-1 family in perinatal inflammation and its clinical implications, with a focus on the potential of these cytokines as therapeutic targets for the development of safe and effective treatments for early life inflammatory diseases.
Keyphrases
- low birth weight
- preterm birth
- white matter
- early life
- anti inflammatory
- oxidative stress
- preterm infants
- pulmonary hypertension
- gestational age
- risk factors
- multiple sclerosis
- heart failure
- acute kidney injury
- intensive care unit
- resting state
- optical coherence tomography
- pregnant women
- pulmonary artery
- atrial fibrillation
- functional connectivity
- septic shock
- risk assessment
- brain injury
- blood brain barrier
- subarachnoid hemorrhage