Enhanced Extracellular Matrix Breakdown Characterizes the Early Distraction Phase of Canine Knee Joint Distraction.

Michelle Teunissen Alberto Miranda BedateKatja CoeleveldFrank M RiemersBjörn P MeijFloris P J G LafeberMarianna A TryfonidouSimon C Mastbergen

Published in: Cartilage (2021)

Joint distraction initiates both catabolic and anabolic transcriptional responses. The enhanced turnover, and thereby renewal of the matrix, could be the key to the cartilage repair observed in the months after joint distraction.

Keyphrases

extracellular matrix
gene expression
transcription factor
oxidative stress