Microenvironment-Triggered Degradable Hydrogel for Imaging Diagnosis and Combined Treatment of Intraocular Choroidal Melanoma.
Luoyuan LiZhenhai ZengZhongxing ChenRongyao GaoLuting PanJun-Jie DengXiuhong YeJun ZhangShuangjie ZhangChenyang MeiJinjin YuYifan FengQinmei WangA-Yong YuMei YangJinhai HuangPublished in: ACS nano (2020)
Human choroidal melanoma (HCM) is one of the most common primary intraocular tumors and easily provokes liver metastases owing to the lack of sensitive and noninvasive therapeutic methods. Concerning the imaging diagnostics and therapeutic predicaments for choroidal melanoma, we designed microenvironment-triggered degradable hydrogels (RENP-ICG@PNIPAM:Dox-FA) based on ultrasmall (<5 nm) rare-earth nanoparticles (RENPs) with enhanced NIR-II luminescence. The ultrasmall diameter can significantly enhance the NIR-II luminescence performance of RENPs. RENPs were encapsulated by a dual-response PNIPAM hydrogel, which could release drug by responding to heat energy and glutathione under the tumor microenvironment. The in vitro/in vivo NIR-II imaging detection and antitumor activity were also compared systematically after different treatment conditions on ocular choroidal melanoma-1 cells and tumor-bearing mice, respectively. Besides, the degradability of the hydrogel composites under physiological conditions could be conducive to enhance the photothermal-chemotherapeutic effect and alleviate long-term biological toxicity. Our work on the microenvironment-triggered hydrogels with enhanced NIR imaging and easy metabolism may provide a promising strategy for sensitive and noninvasive imaging and phototherapy in ocular tumors.
Keyphrases
- high resolution
- fluorescence imaging
- drug delivery
- photodynamic therapy
- drug release
- optical coherence tomography
- stem cells
- optic nerve
- wound healing
- liver metastases
- heart failure
- tissue engineering
- emergency department
- oxidative stress
- fluorescent probe
- adipose tissue
- mass spectrometry
- quantum dots
- skin cancer
- extracellular matrix
- electronic health record
- hypertrophic cardiomyopathy
- cataract surgery