Malignant atrophic papulosis (Degos disease) with central nervous system involvement.
Kundian GuoChunxia JiangBo YanXiaoting HaoPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)
A 49-year-old man presented with a 2-year history of weakness and sensory disturbances in the bilateral lower extremities, vesicorectal dysfunction, and progressive gait disturbances. Brain MRI revealed multiple ischemic and hemorrhagic cortical/subcortical lesions with patchy enhancement involving the frontal and parietal lobes, suggesting the possibility of distal perforating arteries injury. Spine MRI revealed lesions of the cervical and thoracic spinal cord with associated enhancement. The diagnosis of malignant atrophic papulosis (Degos disease) with central nervous system involvement was prompted by the characteristic skin lesions.
Keyphrases
- spinal cord
- contrast enhanced
- magnetic resonance imaging
- white matter
- working memory
- single cell
- soft tissue
- multiple sclerosis
- cerebrospinal fluid
- diffusion weighted imaging
- spinal cord injury
- neuropathic pain
- computed tomography
- minimally invasive
- functional connectivity
- cerebral ischemia
- magnetic resonance
- oxidative stress
- cerebral palsy