RAD18 confers radioresistance of esophagus squamous cell carcinoma through regulating p-DNA-PKcs.
Xiaoqing LiShitao ZouLiangsu ZhouAidi GaoJing XuChao HeJundong ZhouShuhua WuYihong ChenPublished in: Cancer medicine (2022)
These data indicated that RAD18 may regulate radioresistance by facilitating NHEJ via phosphorylation of DNA-PKcs in ESCC cells, providing a novel radiotherapy target for ESCC.
Keyphrases
- circulating tumor
- squamous cell carcinoma
- dna repair
- dna damage
- cell free
- induced apoptosis
- dna damage response
- single molecule
- locally advanced
- cell cycle arrest
- early stage
- cancer stem cells
- radiation therapy
- nucleic acid
- endoplasmic reticulum stress
- radiation induced
- lymph node metastasis
- signaling pathway
- circulating tumor cells
- protein kinase
- cell death
- machine learning
- artificial intelligence
- pi k akt