Login / Signup

Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy.

Chuanrui MaWenwen ZhangXiaoxiao YangYing LiuLipei LiuKe FengXiaomeng ZhangShu YangLei SunMiao YuJie YangXiaoju LiWenquan HuRobert Q MiaoYan ZhuLuyuan LiJihong HanYuanli ChenYajun Duan
Published in: British journal of pharmacology (2018)
Co-treatment with T317 and metformin inhibited the development of atherosclerosis without activation of lipogenesis, suggesting that combined treatment with T317 and metformin may be a novel approach to inhibition of atherosclerosis.
Keyphrases
  • protein kinase
  • cardiovascular disease
  • type diabetes
  • metabolic syndrome
  • adipose tissue
  • skeletal muscle
  • combination therapy
  • replacement therapy
  • smoking cessation