Prevalence and Diagnosis of Latent Tuberculosis Infection in Young Children in the Absence of a Gold Standard.

Tomas Maria Perez-PorcunaHélio Doyle Pereira-da-SilvaCarlos AscasoAdriana MalheiroSamira BührerFlor Martinez-EspinosaRosa Abellana

Published in: PloS one (2016)

This is one of the first studies to estimate the prevalence of LTBI in children and the parameters of the main diagnostic tests using a latent class model. Our results suggest that children in contact with an index case have a high risk of infection. The accuracy and the predictive value of the two tests did not significantly differ. Combined use of the two tests showed scarce improvement in the diagnosis of LTBI.

Keyphrases

young adults
risk factors
mycobacterium tuberculosis
pulmonary tuberculosis
case control
hiv infected