Three-Dimensional Angiographic Characteristics versus Functional Stenosis Severity in Fractional and Coronary Flow Reserve Discordance: A DEFINE FLOW Sub Study.
Valerie StegehuisJelmer WestraCoen K M BoerhoutJelmer WestraAshkan EftekhariHernan Mejía-RenteriaMaribel Cambero-MaderaNiels Van RoyenHitoshi MatsuoMasafumi NakayamaMaria SiebesEvald Høj ChristiansenTim Van de HoefJan PiekPublished in: Diagnostics (Basel, Switzerland) (2022)
Non-flow-limiting lesions (FFR+/CFR-) have 3D-QCA characteristics similar to those of FFR+/CFR+, but the majority are not associated with inducible myocardial ischemia as determined by invasive CFC. FFR-/CFR+ lesions have 3D-QCA characteristics similar to those of FFR-/CFR- lesions but are more frequently associated with a moderately to severely reduced CFC, illustrating the angiographic-functional mismatch in discordant lesions.