Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study.
Caroline J BullJoshua A BellNeil MurphyEleanor SandersonGeorge Davey SmithNicholas J TimpsonBarbara L BanburyDemetrius AlbanesSonja I BerndtStéphane BézieauD Timothy BishopHermann BrennerDaniel D BuchananAndrea Burnett-HartmanGraham CaseySergi Castellví-BelAndrew T ChanJenny Chang-ClaudeAmanda J CrossAlbert de la ChapelleJane C FigueiredoSteven J GallingerSusan M GapsturGraham G GilesStephen B GruberAndrea GsurJochen HampeHeather HampelTabitha A HarrisonMichael HoffmeisterLi HsuWen-Yi HuangJeroen R HuygheMark A JenkinsCorinne E JoshuTemitope O KekuTilman KühnSun-Seog KweonLoic Le MarchandChristopher I LiLi LiAnnika LindblomVicente MartínAnne M MayRoger L MilneVictor MorenoPolly A NewcombKenneth OffitShuji OginoAmanda I PhippsElizabeth A PlatzJohn D PotterConghui QuJ Ramón QuirósGad RennertElio RiboliLori C SakodaClemens SchafmayerRobert E SchoenMartha L SlatteryCatherine M TangenKostas K TsilidisCornelia M UlrichFränzel J B van DuijnhovenBethany van GuelpenKala VisvanathanPavel VodickaLudmila VodickovaHansong WangEmily WhiteAlicja WolkMichael O WoodsAnna H WuPeter T CampbellWei ZhengUlrike PetersEmma E VincentMarc J GunterPublished in: BMC medicine (2020)
Our results suggest that higher BMI more greatly raises CRC risk among men, whereas higher WHR more greatly raises CRC risk among women. Adiposity was associated with numerous metabolic alterations, but none of these explained associations between adiposity and CRC. More detailed metabolomic measures are likely needed to clarify the mechanistic pathways.