Translocator protein-mediated fast-onset antidepressant-like and memory-enhancing effects in chronically stressed mice.

Chao Shang Ru-Meng YaoYing GuoZhen-Chun DingLi-Jun SunYu-Hua RanRui XueHuai-Shan WangJian-Min ZhangYou-Zhi ZhangLi-Ming ZhangYun-Feng Li

Published in: Journal of psychopharmacology (Oxford, England) (2020)

These results suggest that TSPO mediates the fast-onset antidepressant-like and memory-enhancing effects of AC-5216, possibly through the rapid activation of mTOR signalling and restoration of dendritic complexity in the PFC.

Keyphrases

major depressive disorder
working memory
cell proliferation
high fat diet induced
bipolar disorder
protein protein
pet imaging
binding protein
adipose tissue
computed tomography
skeletal muscle
quantum dots