What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen?

Published in: Journal of chemical information and modeling (2020)

Massive drug repurposing (or repositioning) campaigns are trying to find potential antiviral treatments for COVID-19. Many involve experimental or virtual screening of libraries of compounds previously proven safe in humans-"old drugs". In 20 years of these efforts in many other diseases, never has a new therapeutic hypothesis derived from screening of old drugs in a lab led to the drug being approved for the new indication.

Keyphrases

coronavirus disease
sars cov
drug induced
high throughput
respiratory syndrome coronavirus
human health
risk assessment
quality improvement