Circulating miR-16-5p, miR-92a-3p, and miR-451a in Plasma from Lung Cancer Patients: Potential Application in Early Detection and a Regulatory Role in Tumorigenesis Pathways.
Patrícia Pintor ReisSandra A DrigoRobson Francisco CarvalhoRainer Marco Lopez LapaTainara F FelixDevalben PatelDangxiao ChengMelania PintilieGeoffrey LiuMing Sound TsaoPublished in: Cancers (2020)
The 3-miRNA signature (miR-16-5p, miR-92a-3p, miR-451a) had high specificity (100%) and sensitivity (84%) to predict cancer (LUAD and LUSC). These miRNAs are predicted to modulate genes and pathways with known roles in lung tumorigenesis, including EGFR, K-RAS, and PI3K/AKT signaling, suggesting that the 3-miRNA signature is biologically relevant in adenocarcinoma and squamous cell carcinoma of the lung.
Keyphrases
- cell proliferation
- pi k akt
- squamous cell carcinoma
- long non coding rna
- signaling pathway
- end stage renal disease
- small cell lung cancer
- ejection fraction
- long noncoding rna
- newly diagnosed
- peritoneal dialysis
- papillary thyroid
- epidermal growth factor receptor
- locally advanced
- lymph node metastasis
- young adults
- rectal cancer
- genome wide identification