Association of vitamin D-binding protein and vitamin D3 with insulin and homeostatic model assessment (HOMA-IR) in overweight and obese females.
Leila SetayeshKrista CasazzaNariman MoradiSanaz MehranfarHabib YarizadehAbbas AminiMir Saeed YekaninejadKhadijeh MirzaeiPublished in: BMC research notes (2021)
Using the multivariate linear regression, a reverse relationship was observed between VDBP and (HOMA-IR), such that women with higher VDBP displayed lower insulin resistance. The relationship was independent of age, body mass index, standardized energy intake and physical activity (p = 0.00). No significant relationship between 25(OH)D levels, FBS, body composition or insulin resistance were observed (p > 0.2). Current study observed that higher level of VDBP may be associated with lower levels of insulin and HOMA-IR, thus the evaluation of VDBP in diverse population groups seems to have significant clinical value in evaluating the prevalence of DM or early stage of glucose intolerance.
Keyphrases
- body composition
- insulin resistance
- type diabetes
- body mass index
- glycemic control
- physical activity
- early stage
- binding protein
- resistance training
- adipose tissue
- blood glucose
- high fat diet
- metabolic syndrome
- bone mineral density
- skeletal muscle
- weight gain
- high fat diet induced
- risk factors
- radiation therapy
- squamous cell carcinoma
- data analysis
- depressive symptoms