Population pharmacokinetics of vancomycin in paediatric patients with febrile neutropenia and augmented renal clearance: development of new dosing recommendations.
Yuko ShimamotoRuud H J VerstegenTomoyuki MizunoTal SchechterUpton AllenShinya ItoPublished in: The Journal of antimicrobial chemotherapy (2021)
ARC is frequently observed in paediatric patients with post-HSCT febrile neutropenia, resulting in a significant increase in vancomycin clearance. We propose a vancomycin dosing strategy for children with febrile neutropenia following HSCT based on eGFR, age, weight and body temperature.
Keyphrases
- chemotherapy induced
- methicillin resistant staphylococcus aureus
- intensive care unit
- emergency department
- urinary tract infection
- small cell lung cancer
- hematopoietic stem cell
- young adults
- body mass index
- epidermal growth factor receptor
- physical activity
- weight loss
- staphylococcus aureus
- body weight
- virtual reality