Crosstalk between E2F1 and P53 transcription factors in doxorubicin-induced DNA damage: evidence for preventive/protective effects of silymarin.

Seyedeh-Khadijeh Shafiei-RoudbariHassan MalekinejadHamed Janbaz-AciabarMazdak Razi

Published in: The Journal of pharmacy and pharmacology (2017)

DOX-induced testicular toxicity was characterized by lowering sperm quality values, induction of oxidative and nitrosative stress and DNA fragmentation. Preventive and protective effects of SMN on DOX-induced testicular toxicity may attribute to its antioxidant property. DOX-induced testicular damages and SMN preventive/protective effects might be mediated via up- and down-regulation of p53 and E2F1 transcription factors.

Keyphrases

high glucose
diabetic rats
oxidative stress
dna damage
transcription factor
drug induced
endothelial cells
germ cell
dna repair
single molecule