Clozapine-loaded nanocapsules improve antipsychotic activity in rats: building a sequential PopPK/PD model to discriminate nanocarriers in the preformulation step.
Ana Cláudia Funguetto-RibeiroTamara Ramos MacielAnnelize Gruppi LunardiDaniel Borges GomesManuel IbarraSandra Elisa HaasPublished in: Pharmaceutical research (2023)
Our model discriminates the coatings and describes the peculiar PK and PD behavior of nanoencapsulated CZP, especially NCCS, making it an exciting tool for evaluating the preclinical performance of nanoparticles.